Location: Bristol, PA, US
The available position is for a highly motivated, accomplished researcher who will join the Bioconjugate Chemistry group at Abzena and who will be responsible for contributing to the optimization and development of bioconjugation processes, including but not limited to the areas of Antibody Drug Conjugates (ADCs), Fluorescent-Probe Bioconjugation and Protein-Protein cross-linking. The candidate will also be responsible for the planning of synthetic routes/strategies, the execution and delivery of bioorganic synthesis projects for Abzena’s clients. This will include the preparation, purification and characterization of all materials, maintaining clear and current records of their work within a laboratory notebook and performing all applicable analytical work.
The ideal candidate will possess a MS or Ph.D. in biochemistry, chemistry, protein chemistry or related discipline with 1-5+ years of applicable technical experience in these areas. Candidates must possess a strong background in the theory and practice of bioorganic and protein chemistry, possess excellent problem solving skills and demonstrate a thorough understanding of protein chemistry, protein handling, purification and characterization. Must be able to independently prioritize own work assignments, and consistently demonstrate the ability to perform assigned tasks through rigorous data collection and applying analytical tests and instrumentation in the laboratory. The candidate must have expertise in the purification and characterization of proteins and protein conjugates using applicable modern techniques. Candidate must be comfortable with routine use of HPLC, LC/MS, FPLC (affinity purification, size exclusion chromatography, hydrophobic interaction chromatography, etc.), SDS-PAGE and UV-VIS spectroscopy.