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The biopharmaceutical development process starts with target identification and antibody discovery. Abzena offers multiple approaches to antibody discovery and the isolation, development and selection of lead antibodies.
Phage display technology, using naïve and immune libraries (from a variety of species, including llamas), can be used to identify lead candidates against a vast range of targets, including:
|TNF superfamily receptors and ligands||Blood proteins|
|Brain neurology targets||Tumour biomarkers|
|Cytokines and receptors||Immunoglobulins|
|T cell activators, ligands and receptors||Checkpoint modulators|
|Non protein targets|
In a phage display library billions of antibody fragments, Fabs, are displayed on the surface of M13 bacteriophage and presented to the target antigen in order to select target-specific binders. These binders can then be re-formatted, if desired, into a variety of configurations including monoclonal antibodies (mAbs) and bi-specific antibodies (BsAb). The flexibility of the phage display-based discovery process enables the identification of binders with very specific characteristics from a number of different library types, which can be selected depending upon the nature of the project.
The human library contains over 10 billion antibodies derived from multiple human donor peripheral blood cells, in a Fab format, displayed on the bacteriophage surface. The Fab format provides better retention of binding activity and is less prone to aggregation and spurious binding effects than libraries using single-chain antibodies (scFvs).
The llama single domain antibody library contains 1.5 billion VHH domains and can be used to select against virtually any antigen. Naïve libraries are ideal for use when antigen availability is limited or the antigen is toxic.
Working with Abzena
Abzena’s services are tailored for each project to ensure that the objectives are met or exceeded. Experienced project teams are assigned to each study focusing on progressing projects through to results in the minimum amount of time. Our clients widely regard us as professional and attentive partners who deliver quality results.
For more information or a quote for our antibody discovery services contact us.
Abzena discovery services are offered in collaboration with: